Familial cancer risk assessment
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- THE IMPORTANCE OF THE HEREDITARY RISK FACTORS IN THE NEOPLAZIC DISEASE
Cancer—a definition. Term represents a group of more than neoplastic diseases that involve all body organs. One or more familial cancer risk assessment lose their normal growth controlling mechanism and continue to grow uncontrolled. They tend to invade surrounding tissue and to metastasize to distant body sites.
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Second leading cause of death in United States after heart disease. Ranks fourth for males and first for females as cause of death; second after accidents as cause of death for children.
Cancerul ovarian si mutatiile BRCA Importanta mutatiilor genetice in evolutia cancerului ovarian Aflati cum va puteti imbunatatiti perspectivele cu un simplu test Cancerul ovarian este relativ rar locul 5 ca incidenta intre cancerele feminineinsa datorita simptomelor nespecifice, tinde sa fie diagnosticat in faze avansate. Mutatiile genetice joaca un rol important in determinarea riscurilor de aparitie, dar si de evolutie a bolii. Aceste mutatii pot fi mostenite de la parinti, sau pot fi dobandite pe parcursul vietii.
Greatest increase seen in lung cancer—consistent with smoking patterns. Incidence rate.
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It is predicted that the incidence of cancer in the United States could double by the middle of the century, due to growth and aging of population. Leading causes of cancer death are lungs, prostate, and colorectal for males; lungs, breast, and colorectal for females.
Most common site of cancer for a female is the cervix. Steps in controlling cancer: Educate the public and professional people about cancer.
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Encourage methods of primary prevention. Carcinogens: agents known to increase susceptibility to cancer. Chemical carcinogens: asbestos, benzene, vinyl chloride, by-products of tobacco, arsenic, cadmium, nickel, radiation, and mustard gas.
Iatrogenic chemical agents: diethylstilbestrol DES ; chemotherapy; hormone treatment; immunosuppressive agents, radioisotopes, cytotoxic drugs. Radiation carcinogens: x-rays; sunlight ultraviolet light ; nuclear radiation. Viral factors: herpes simplex; Epstein—Barr; hepatitis B, and retroviruses.
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Genetic factors: hereditary or familial tendencies. Demographic and geographic factors. Dietary factors: obesity; high-fat diet; diets low in fiber; diets high in smoked or salted foods; preservatives and food additives; alcohol.
Psychological factors: stress. Optimal dietary patterns and lifestyle changes. Increase total fiber in diet—decreases risk of colon cancer.
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Increase cruciferous vegetables cabbage, broccoli, carrots, Brussels sprouts. Increase vitamin A—reduced incidence of larynx, esophagus, and lung cancers. Increase vitamin C—aids tumor encapsulation and promotes longer survival time. Increase vitamin E—inhibits growth of brain tumors, melanomas, and leukemias.
- Sindromul cancerului ereditar — genetica și cancerul Sindromul cancerului ereditar - genetica și cancerul - Cancer Informații generale myCancerRiskDNA - evaluare risc cancer ereditar, profil genetic extins Synevo Familial cancer risk assessment, PMS2 TP53 APC — gena care codifica pentru o proteina cu rol critic in diferite procese celulare, actionand ca un supresor al cresterii tumorale.
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Decrease alcohol consumption. Avoid salt—cured, smoked, or nitrate-cured foods. Minimize exposure to carcinogens. Avoid oral tobacco—increases incidence of oral cancers.
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Avoid exposure to asbestos fibers and constant environmental dust. Avoid exposure to chemicals. Avoid radiation exposure and excessive exposure to sunlight. Obtain adequate rest and exercise to decrease stress. Chronic stress associated with decreased immune system functioning.
THE IMPORTANCE OF THE HEREDITARY RISK FACTORS IN THE NEOPLAZIC DISEASE
Strong immune system responsible for destruction of developing malignant cells. Participate in a regular exercise program.
Familial cancer risk assessment adequate rest 6—8 hours per night. Have a physical exam on a regular basis, including recommended diagnostic tests.
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Risk assessment see Identified Causes and Risk Factors, p. Health history and physical assessment.
Screening methods. Tratamentul condiloamelor ambilor parteneri, Pap test, prostate exam, prostate- specific antigen PSA blood test, etc.
Self-care practices: breast self-examination BSE done every month on a regular time schedule; testicular self-examination TSE done every month; skin inspection.
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Colonoscopy for males and females 50 years and older. Fecal occult blood test for males and females 40 years and older.
Characteristics A. Benign neoplasms: usually encapsulated, remain localized, and are slow growing.
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Malignant neoplasms: not encapsulated, will metastasize and grow, and exert negative effects on host. Categories of malignant neoplasms.
Există tot mai multe dovezi că, abordarea multidisciplinară îmbunătățește rezultatele îngrijirii oferite pacientului oncologic, având efecte benefice și asupra profesioniștilor din echipa multidisciplinară Sainsbury, et al.
Carcinomas—grown from epithelial cells; usually solid tumors skin, stomach, colon, breast, rectal.